Publications

Scientific exchange is key for us to keep pace with latest developments in our field. Only in this way we are in position to provide fit-for-purpose solutions.
Part of this process is to publish our work in the scientific literature.

A selection – grouped by topics - from more than 50 publication is listed here:

Validation

Validation Study on the Ocular Irritection© Assay for Eye Irritation Testing Show DetailsHide Details

Eskes C, Hoffmann S, Facchini D, Ulmer R, Wang A, Flego M, Vassallo M, Bufo M, van Vliet E, d’Abrosca F, Wilt N
Toxicol in Vitro. 2014, in press, available online 14 March 2014
Link to paper

Use of the Cultex© Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility Show DetailsHide Details

Steinritz D, Moehle N, Pohl C, Papritz M, Stenger B, Schmidt A, Kirkpatrick CJ, Thiermann H, Vogel R, Hoffmann S, Aufderheide M
Chem Biol Interact. 2013 Dec 5;206(3):479-90
Link to Abstract

ECVAM prevalidation of three cell transformation assays Show DetailsHide Details

Vanparys P, Corvi R, Aardema M, Gribaldo L, Hayashi M, Hoffmann S, Schechtman L
ALTEX. 2011; 28(1), 56 - 59
Link to paper

ECVAM retrospective validation of in vitro micronucleus test (MNT) Show DetailsHide Details

Corvi R, Albertini S, Hartung T, Hoffmann S, Maurici D, Pfuhler S, van Benthem J, Vanparys P
Mutagenesis. 2008 Jul;23(4):271-83
Link to Abstract

Points of reference in the validation process: the report and recommendations of ECVAM Workshop 66 Show DetailsHide Details

Hoffmann S, Edler L, Gardner I, Gribaldo L, Hartung T, Klein C, Liebsch M, Sauerland S, Schechtman L, Stammati A, Nikolaidis E
Altern Lab Anim. 2008 Jul;36(3):343-52
Link to paper

The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test Show DetailsHide Details

Spielmann H, Hoffmann S, Liebsch M, Botham P, Fentem JH, Eskes C, Roguet R, Cotovio J, Cole T, Worth A, Heylings J, Jones P, Robles C, Kandárová H, Gamer A, Remmele M, Curren R, Raabe H, Cockshott A, Gerner I, Zuang V
Altern Lab Anim. 2007 Dec;35(6):559-601
Link to Abstract

ECVAM. The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58 Show DetailsHide Details

Balls M, Amcoff P, Bremer S, Casati S, Coecke S, Clothier R, Combes R, Corvi R, Curren R, Eskes C, Fentem J, Gribaldo L, Halder M, Hartung T, Hoffmann S, Schectman L, Scott L, Spielmann H, Stokes W, Tice R, Wagner D, Zuang V
Altern Lab Anim. 2006 Dec;34(6):603-20
Link to Abstract

Designing validation studies more efficiently according to the modular approach: retrospective analysis of the EPISKIN test for skin corrosion Show DetailsHide Details

Hoffmann S, Hartung T
Altern Lab Anim. 2006 May;34(2):177-91
Link to paper

International validation of novel pyrogen tests based on human monocytoid cells Show DetailsHide Details

Hoffmann S, Peterbauer A, Schindler S, Fennrich S, Poole S, Mistry Y, Montag-Lessing T, Spreitzer I, Löschner B, van Aalderen M, Bos R, Gommer M, Nibbeling R, Werner-Felmayer G, Loitzl P, Jungi T, Brcic M, Brügger P, Frey E, Bowe G, Casado J, Coecke S, de Lange J, Mogster B, Naess LM, Aaberge IS, Wendel A, Hartung T
J Immunol Methods. 2005 Mar;298(1-2):161-73
Link to Abstract

A modular approach to the ECVAM principles on test validitye Show DetailsHide Details

Hartung T, Bremer S, Casati S, Coecke S, Corvi R, Fortaner S, Gribaldo L, Halder M, Hoffmann S, Roi AJ, Prieto P, Sabbioni E, Scott L, Worth A, Zuang V
Altern Lab Anim. 2004 Nov;32(5):467-72
Link to paper

Testing Strategies

Integrated Testing Strategy (ITS) - Opportunities to better use existing data and guide future testing in toxicology Show DetailsHide Details

Jaworska J and Hoffmann S
ALTEX. 2010; 27(4):231-242
Link to paper

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches Show DetailsHide Details

Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V
Toxicol In Vitro. 2010 Feb;24(1):1-9
Link to Abstract

A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals Show DetailsHide Details

Hoffmann S, Saliner AG, Patlewicz G, Eskes C, Zuang V, Worth AP
Toxicol Lett. 2008 Jul 30;180(1):9-20
Link to Abstract

EBT

Mechanistic validation Show DetailsHide Details

Hartung T, Hoffmann S, Stephens M
ALTEX. 2013;30(2):119-30
Link to paper

"ToxRTool", a new tool to assess the reliability of toxicological data Show DetailsHide Details

Schneider K, Schwarz M, Burkholder I, Kopp-Schneider A, Edler L, Kinsner-Ovaskainen A, Hartung T, Hoffmann S
Toxicol Lett. 2009 Sep 10;189(2):138-44
Link to Abstract

Toward an evidence-based toxicology Show DetailsHide Details

Hoffmann S, Hartung T
Hum Exp Toxicol. 2006 Sep;25(9):497-513. Review
Link to Abstract

Diagnosis: toxic! -- Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations Show DetailsHide Details

Hoffmann S, Hartung T
Toxicol Sci. 2005 May;85(1):422-8
Link to paper

Other

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods Show DetailsHide Details

Adriaens E, Barroso J, Eskes C, Hoffmann S, McNamee P, Alépée N, Bessou-Touya S, De Smedt A, De Wever B, Pfannenbecker U, Tailhardat M, Zuang V
Arch Toxicol. 2014 Mar;88(3):701-23
Link to Abstract

Skin irritation: prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals Show DetailsHide Details

Hoffmann S, Cole T, Hartung T
Regul Toxicol Pharmacol. 2005 Apr;41(3):159-66
Link to Abstract

ValidationValidation Study on the Ocular Irritection© Assay for Eye Irritation Testing
Eskes C, Hoffmann S, Facchini D, Ulmer R, Wang A, Flego M, Vassallo M, Bufo M, van Vliet E, d’Abrosca F, Wilt N
Toxicol in Vitro. 2014, in press, available online 14 March 2014
Link to paperUse of the Cultex© Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility
Steinritz D, Moehle N, Pohl C, Papritz M, Stenger B, Schmidt A, Kirkpatrick CJ, Thiermann H, Vogel R, Hoffmann S, Aufderheide M
Chem Biol Interact. 2013 Dec 5;206(3):479-90
Link to AbstractECVAM prevalidation of three cell transformation assays
Vanparys P, Corvi R, Aardema M, Gribaldo L, Hayashi M, Hoffmann S, Schechtman L
ALTEX. 2011; 28(1), 56 - 59
Link to paperECVAM retrospective validation of in vitro micronucleus test (MNT)
Corvi R, Albertini S, Hartung T, Hoffmann S, Maurici D, Pfuhler S, van Benthem J, Vanparys P
Mutagenesis. 2008 Jul;23(4):271-83
Link to AbstractPoints of reference in the validation process: the report and recommendations of ECVAM Workshop 66
Hoffmann S, Edler L, Gardner I, Gribaldo L, Hartung T, Klein C, Liebsch M, Sauerland S, Schechtman L, Stammati A, Nikolaidis E
Altern Lab Anim. 2008 Jul;36(3):343-52
Link to paperThe ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test
Spielmann H, Hoffmann S, Liebsch M, Botham P, Fentem JH, Eskes C, Roguet R, Cotovio J, Cole T, Worth A, Heylings J, Jones P, Robles C, Kandárová H, Gamer A, Remmele M, Curren R, Raabe H, Cockshott A, Gerner I, Zuang V
Altern Lab Anim. 2007 Dec;35(6):559-601
Link to AbstractECVAM. The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58
Balls M, Amcoff P, Bremer S, Casati S, Coecke S, Clothier R, Combes R, Corvi R, Curren R, Eskes C, Fentem J, Gribaldo L, Halder M, Hartung T, Hoffmann S, Schectman L, Scott L, Spielmann H, Stokes W, Tice R, Wagner D, Zuang V
Altern Lab Anim. 2006 Dec;34(6):603-20
Link to AbstractDesigning validation studies more efficiently according to the modular approach: retrospective analysis of the EPISKIN test for skin corrosion
Hoffmann S, Hartung T
Altern Lab Anim. 2006 May;34(2):177-91
Link to paperInternational validation of novel pyrogen tests based on human monocytoid cells
Hoffmann S, Peterbauer A, Schindler S, Fennrich S, Poole S, Mistry Y, Montag-Lessing T, Spreitzer I, Löschner B, van Aalderen M, Bos R, Gommer M, Nibbeling R, Werner-Felmayer G, Loitzl P, Jungi T, Brcic M, Brügger P, Frey E, Bowe G, Casado J, Coecke S, de Lange J, Mogster B, Naess LM, Aaberge IS, Wendel A, Hartung T
J Immunol Methods. 2005 Mar;298(1-2):161-73
Link to AbstractA modular approach to the ECVAM principles on test validitye
Hartung T, Bremer S, Casati S, Coecke S, Corvi R, Fortaner S, Gribaldo L, Halder M, Hoffmann S, Roi AJ, Prieto P, Sabbioni E, Scott L, Worth A, Zuang V
Altern Lab Anim. 2004 Nov;32(5):467-72
Link to paperTesting StrategiesIntegrated Testing Strategy (ITS) - Opportunities to better use existing data and guide future testing in toxicology
Jaworska J and Hoffmann S
ALTEX. 2010; 27(4):231-242
Link to paperA proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V
Toxicol In Vitro. 2010 Feb;24(1):1-9
Link to AbstractA feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals
Hoffmann S, Saliner AG, Patlewicz G, Eskes C, Zuang V, Worth AP
Toxicol Lett. 2008 Jul 30;180(1):9-20
Link to AbstractEBTMechanistic validation
Hartung T, Hoffmann S, Stephens M
ALTEX. 2013;30(2):119-30
Link to paper"ToxRTool", a new tool to assess the reliability of toxicological data
Schneider K, Schwarz M, Burkholder I, Kopp-Schneider A, Edler L, Kinsner-Ovaskainen A, Hartung T, Hoffmann S
Toxicol Lett. 2009 Sep 10;189(2):138-44
Link to AbstractToward an evidence-based toxicology
Hoffmann S, Hartung T
Hum Exp Toxicol. 2006 Sep;25(9):497-513. Review
Link to AbstractDiagnosis: toxic! -- Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations
Hoffmann S, Hartung T
Toxicol Sci. 2005 May;85(1):422-8
Link to paperOtherRetrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods
Adriaens E, Barroso J, Eskes C, Hoffmann S, McNamee P, Alépée N, Bessou-Touya S, De Smedt A, De Wever B, Pfannenbecker U, Tailhardat M, Zuang V
Arch Toxicol. 2014 Mar;88(3):701-23
Link to AbstractSkin irritation: prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals
Hoffmann S, Cole T, Hartung T
Regul Toxicol Pharmacol. 2005 Apr;41(3):159-66
Link to Abstract

Publications

Validation

Testing Strategies

EBT

Other

seh consulting + servicesSebastian HoffmannPhD

seh consulting + services