Publications

Scientific exchange is key for us to keep pace with latest developments in our field. Only in this way we are in position to provide fit-for-purpose solutions.
Part of this process is to publish our work in the scientific literature.

A selection – grouped by topics - from more than 50 publication is listed here:

Validation

Validation Study on the Ocular Irritection© Assay for Eye Irritation Testing Show DetailsHide Details
Eskes C, Hoffmann S, Facchini D, Ulmer R, Wang A, Flego M, Vassallo M, Bufo M, van Vliet E, d’Abrosca F, Wilt N
Toxicol in Vitro. 2014, in press, available online 14 March 2014
Link to paper
Use of the Cultex© Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility Show DetailsHide Details
Steinritz D, Moehle N, Pohl C, Papritz M, Stenger B, Schmidt A, Kirkpatrick CJ, Thiermann H, Vogel R, Hoffmann S, Aufderheide M
Chem Biol Interact. 2013 Dec 5;206(3):479-90
Link to Abstract
ECVAM prevalidation of three cell transformation assays Show DetailsHide Details
Vanparys P, Corvi R, Aardema M, Gribaldo L, Hayashi M, Hoffmann S, Schechtman L
ALTEX. 2011; 28(1), 56 - 59
Link to paper
ECVAM retrospective validation of in vitro micronucleus test (MNT) Show DetailsHide Details
Corvi R, Albertini S, Hartung T, Hoffmann S, Maurici D, Pfuhler S, van Benthem J, Vanparys P
Mutagenesis. 2008 Jul;23(4):271-83
Link to Abstract
Points of reference in the validation process: the report and recommendations of ECVAM Workshop 66 Show DetailsHide Details
Hoffmann S, Edler L, Gardner I, Gribaldo L, Hartung T, Klein C, Liebsch M, Sauerland S, Schechtman L, Stammati A, Nikolaidis E
Altern Lab Anim. 2008 Jul;36(3):343-52
Link to paper
The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test Show DetailsHide Details
Spielmann H, Hoffmann S, Liebsch M, Botham P, Fentem JH, Eskes C, Roguet R, Cotovio J, Cole T, Worth A, Heylings J, Jones P, Robles C, Kandárová H, Gamer A, Remmele M, Curren R, Raabe H, Cockshott A, Gerner I, Zuang V
Altern Lab Anim. 2007 Dec;35(6):559-601
Link to Abstract
ECVAM. The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58 Show DetailsHide Details
Balls M, Amcoff P, Bremer S, Casati S, Coecke S, Clothier R, Combes R, Corvi R, Curren R, Eskes C, Fentem J, Gribaldo L, Halder M, Hartung T, Hoffmann S, Schectman L, Scott L, Spielmann H, Stokes W, Tice R, Wagner D, Zuang V
Altern Lab Anim. 2006 Dec;34(6):603-20
Link to Abstract
Designing validation studies more efficiently according to the modular approach: retrospective analysis of the EPISKIN test for skin corrosion Show DetailsHide Details
Hoffmann S, Hartung T
Altern Lab Anim. 2006 May;34(2):177-91
Link to paper
International validation of novel pyrogen tests based on human monocytoid cells Show DetailsHide Details
Hoffmann S, Peterbauer A, Schindler S, Fennrich S, Poole S, Mistry Y, Montag-Lessing T, Spreitzer I, Löschner B, van Aalderen M, Bos R, Gommer M, Nibbeling R, Werner-Felmayer G, Loitzl P, Jungi T, Brcic M, Brügger P, Frey E, Bowe G, Casado J, Coecke S, de Lange J, Mogster B, Naess LM, Aaberge IS, Wendel A, Hartung T
J Immunol Methods. 2005 Mar;298(1-2):161-73
Link to Abstract
A modular approach to the ECVAM principles on test validitye Show DetailsHide Details
Hartung T, Bremer S, Casati S, Coecke S, Corvi R, Fortaner S, Gribaldo L, Halder M, Hoffmann S, Roi AJ, Prieto P, Sabbioni E, Scott L, Worth A, Zuang V
Altern Lab Anim. 2004 Nov;32(5):467-72
Link to paper

Testing Strategies

Integrated Testing Strategy (ITS) - Opportunities to better use existing data and guide future testing in toxicology Show DetailsHide Details
Jaworska J and Hoffmann S
ALTEX. 2010; 27(4):231-242
Link to paper
A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches Show DetailsHide Details
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V
Toxicol In Vitro. 2010 Feb;24(1):1-9
Link to Abstract
A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals Show DetailsHide Details
Hoffmann S, Saliner AG, Patlewicz G, Eskes C, Zuang V, Worth AP
Toxicol Lett. 2008 Jul 30;180(1):9-20
Link to Abstract

EBT

Mechanistic validation Show DetailsHide Details
Hartung T, Hoffmann S, Stephens M
ALTEX. 2013;30(2):119-30
Link to paper
"ToxRTool", a new tool to assess the reliability of toxicological data Show DetailsHide Details
Schneider K, Schwarz M, Burkholder I, Kopp-Schneider A, Edler L, Kinsner-Ovaskainen A, Hartung T, Hoffmann S
Toxicol Lett. 2009 Sep 10;189(2):138-44
Link to Abstract
Toward an evidence-based toxicology Show DetailsHide Details
Hoffmann S, Hartung T
Hum Exp Toxicol. 2006 Sep;25(9):497-513. Review
Link to Abstract
Diagnosis: toxic! -- Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations Show DetailsHide Details
Hoffmann S, Hartung T
Toxicol Sci. 2005 May;85(1):422-8
Link to paper

Other

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods Show DetailsHide Details
Adriaens E, Barroso J, Eskes C, Hoffmann S, McNamee P, Alépée N, Bessou-Touya S, De Smedt A, De Wever B, Pfannenbecker U, Tailhardat M, Zuang V
Arch Toxicol. 2014 Mar;88(3):701-23
Link to Abstract
Skin irritation: prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals Show DetailsHide Details
Hoffmann S, Cole T, Hartung T
Regul Toxicol Pharmacol. 2005 Apr;41(3):159-66
Link to Abstract

seh consulting + servicesSebastian HoffmannPhD

Stembergring 15
33106 Paderborn
Germany

Fon: +49 (0) 52 51/ 87 00 56 6
Mail: info@seh-cs.com

LinkedIn-Profile - Dr. Sebastian Hoffmann
ResearchGate-Profile - Dr. Sebastian Hoffmann
XING-Profile - Dr. Sebastian Hoffmann

seh consulting + services

Stembergring 15 - 33106 Paderborn
Germany

Fon: +49 (0) 52 51/ 87 00 56 6
Mail: info@seh-cs.com

LinkedIn-Profile of Dr. Sebastian Hoffmann ResearchGate-Profile of Dr. Sebastian Hoffmann XING-Profile of Dr. Sebastian Hoffmann

seh consulting + services
Stembergring 15
33106 Paderborn
Germany